1545 was an annus horribilis for Tudor England and its corpulent tyrant. Not only did Henry VIII's best friend, the Duke of Suffolk, die, but the war with France was at an expensive stalemate after the withdrawal of Charles V from the Italian War. Domestically, Tudor England was ravaged by two concurrent epidemics, the plague outbreak in 1544-46 and the bloody flux spread into England by soldiers who had been fighting at Boulogne. What if either one of these diseases had "decided" to round off Henry's already terrible year by killing his only son and heir, Edward, Prince of Wales (the future Edward VI)? How would the course of English history have been impacted by the lack of Edward VI's reign, which witnessed a shift in the Church of England from Henry's "Catholicism without the Pope" in a more Protestant direction?
Incidentally, Edward VI dying young, whether as Prince of Wales or King during Somerset's Regency during 1547-49 would probably have been off better off for England, given how the Somerset and Northumberland Regencies proved to be even more disastrous for England's foreign policy than the last decade or so of Henry VIII's reign. After all, his death would end the War of the Rough Wooing early, which in turn would have led to Mary, Queen of Scots, not being sent off to France and not becoming Dauphinne(and later Queen) of France through marriage. Francis II's untimely death in 1560, which ended the Franco-Scottish encirclement of England, can only be considered a stroke of heavenly fortune for Elizabeth and her reign.
Incidentally, Edward VI dying young, whether as Prince of Wales or King during Somerset's Regency during 1547-49 would probably have been off better off for England, given how the Somerset and Northumberland Regencies proved to be even more disastrous for England's foreign policy than the last decade or so of Henry VIII's reign. After all, his death would end the War of the Rough Wooing early, which in turn would have led to Mary, Queen of Scots, not being sent off to France and not becoming Dauphinne(and later Queen) of France through marriage. Francis II's untimely death in 1560, which ended the Franco-Scottish encirclement of England, can only be considered a stroke of heavenly fortune for Elizabeth and her reign.