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Philip II, King of Spain (b. 1527) married a) Maria Manuela of Portugal (b. 1527-1545) in 1543, b) Mary, Queen of England (1516-1560) in 1554, c) Anna of Austria (b. 1549) in 1565
  1. a) Charles, Prince of Asturias and Girona (1545-1568) married Elisabeth of France (1545-1568) in 1559 with issue
    1. Philip (1561)
    2. stillborn twin girls (1564)
    3. Isabella II, Queen of Spain (b. 1566) married Ferdinand VI, King of Spain (b. 1566)
    4. Charles I, King of Portugal (1567-1572)
    5. Catherine (1568)
  2. b) Katherine Isabella, Queen of England and Duchess of Burgundy (b. 1555) married Ernest I, King of England (b. 1553) with issue
  3. c) Ferdinand VI, King of Spain (b. 1566) married Isabella II, Queen of Spain (b. 1566)
  4. c) Juana Manuela (1568-1574)
  5. c) Leonora Maria (b. 1570)
  6. c) Isabella Clara Eugenia (1572-1575)
  7. c) Diego (b. 1575)
 
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