Catherine of Aragon is Queen regent for eight years old, Mary I along with Cardinal Thomas Wolsey, Bishop of York
Potential spouses:
- Henry Howard, Earl of Surrey (c. 1516) the eldest son of Thomas Howard, 3rd Duke of Norfolk by his second wife Elizabeth Stafford, a daughter of executed, Edward Stafford, 3rd Duke of Buckingham. He was thus descended from King Edward I on his father's side and from King Edward III on his mother's side.
- William Howard, 1st Baron Howard of Effingham (c. 1510–12/1/1573) another son of Thomas Howard.
-Henry Fitzalan, 12th Earl of Arundel KG (23 April 1512 – 24 February 1580) the only son of William Fitzalan, 11th Earl of Arundel, and his second wife Anne Percy, daughter of Henry Percy, 4th Earl of Northumberland, and was named for Henry VIII, who personally stood as his godfather at his baptism.
- Thomas Seymour, 1st Baron Seymour of Sudeley (c. 1508 – 20 March 1549) son of
Sir John Seymour and
Margaret Wentworth. He was the younger brother of
Edward Seymour, 1st Duke of Somerset (1500–1552).
A foreign match could create complications with unions but possible foreign husbands:
- Ferdinand of Aragon and Castile (10 March 1503 – 25 July 1564) if he denounces his brothers claim.
Any of the younger sons of Manuel I of Portugal and his wife Maria of Aragon (sister of Catherine of Aragon)
Prince Ferdinand (5 June 1507-7 November 1534)
Prince Afonso (23 April 1509-21 April 1540)
Prince Henry (31 January 1512-31 January 1580)
Prince Edward (7 October 1515-20 September 1540)